Masayuki Ishihara Selected Research

liposome-encapsulated hemoglobin

4/2023	Liposome-Encapsulated Hemoglobin Vesicle Improves Persistent Anti-arrhythmogenesis through Improving Myocardial Electrical Remodeling and Modulating Cardiac Autonomic Activity in a Hemorrhagic Shock-Induced Rat Heart Model.
11/2021	Liposome-encapsulated hemoglobin (HbV) transfusion rescues rats undergoing progressive lethal 85% hemorrhage as a result of an anti-arrhythmogenic effect on the myocardium.
1/2019	Myocardial Electrical Remodeling and the Arrhythmogenic Substrate in Hemorrhagic Shock-Induced Heart: Anti-Arrhythmogenic Effect of Liposome-Encapsulated Hemoglobin (HbV) on the Myocardium.
8/2012	Liposome-encapsulated hemoglobin attenuates cardiac dysfunction and sympathetic activity during hypohemoglobinemic shock.
1/2011	Intraosseous transfusion with liposome-encapsulated hemoglobin improves mouse survival after hypohemoglobinemic shock without scavenging nitric oxide.
8/2008	Liposome-encapsulated hemoglobin transfusion rescues rats undergoing progressive hemodilution from lethal organ hypoxia without scavenging nitric oxide.

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Masayuki Ishihara Research Topics

Disease

29	Wounds and Injuries (Trauma) 10/2022 - 02/2002
10	Hemorrhage 01/2023 - 02/2002
9	Neoplasms (Cancer) 01/2023 - 11/2004
8	Infections 03/2022 - 09/2004
6	Ischemia 01/2016 - 01/2007
6	Coronary Artery Disease (Coronary Atherosclerosis) 11/2006 - 05/2004
5	Congenital Abnormalities (Deformity) 11/2023 - 03/2022
4	Hypoxia (Hypoxemia) 08/2013 - 08/2008
3	Lordosis 11/2023 - 03/2022
3	Hemorrhagic Shock 04/2023 - 01/2011
3	Pathologic Constriction (Stenosis) 04/2019 - 05/2004
3	Myocardial Infarction 09/2010 - 06/2005
2	Spinal Injuries (Spinal Injury) 03/2024 - 01/2023
2	Respiratory Insufficiency (Respiratory Failure) 01/2024 - 05/2010
2	Scoliosis 11/2023 - 10/2023
2	Atrial Remodeling 04/2023 - 01/2019
2	Thrombotic Microangiopathies 01/2023 - 01/2022
2	Glomerulonephritis 01/2023 - 01/2022
2	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2022 - 07/2012
2	Thrombosis (Thrombus) 04/2019 - 10/2011
2	Acute Kidney Injury (Acute Renal Failure) 01/2015 - 09/2012
2	Chronic Renal Insufficiency 12/2013 - 10/2012
2	Chronic Limb-Threatening Ischemia 01/2013 - 09/2011
2	Peripheral Arterial Disease 01/2013 - 09/2011
2	Shock 08/2012 - 01/2011
2	Heart Diseases (Heart Disease) 01/2009 - 08/2007
2	Myocardial Ischemia (Ischemic Heart Diseases) 04/2006 - 10/2004
1	Ossification of Posterior Longitudinal Ligament 01/2024
1	Hypoalbuminemia 01/2024
1	Paralysis (Palsy) 01/2024
1	Hematoma 01/2024
1	Kyphosis 11/2023
1	Low Back Pain (Lumbago) 10/2023
1	Frailty 02/2023
1	Dementia (Dementias) 02/2023
1	Diffuse Idiopathic Skeletal Hyperostosis 01/2023
1	Metabolic Bone Diseases (Osteopenia) 01/2023
1	Hepatocellular Carcinoma (Hepatoma) 01/2023
1	Spinal Cord Injuries (Spinal Cord Injury) 08/2022

Drug/Important Bio-Agent (IBA)

18	ChitosanIBA 06/2015 - 02/2002
15	HydrogelsIBA 09/2013 - 02/2002
10	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2018 - 09/2003
9	Proteins (Proteins, Gene)FDA Link 08/2020 - 03/2008
6	liposome-encapsulated hemoglobinIBA 04/2023 - 08/2008
6	Protamines (Protamine Sulfate)FDA Link 01/2018 - 09/2011
5	Oxygen (Dioxygen)IBA 11/2021 - 08/2008
4	Tissue Adhesives (Tissue Adhesive)IBA 04/2019 - 02/2002
4	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 01/2018 - 06/2015
4	Dalteparin (Dalteparin Sodium)FDA Link 10/2015 - 09/2011
4	Mitomycin (Mitomycin-C)FDA LinkGeneric 10/2015 - 07/2007
4	ChitinIBA 06/2015 - 01/2010
4	AlginatesIBA 05/2013 - 01/2010
3	AnticoagulantsIBA 10/2022 - 01/2007
3	SuspensionsIBA 06/2020 - 11/2012
3	Povidone-Iodine (Betadine)FDA LinkGeneric 06/2020 - 01/2020
3	Indicators and Reagents (Reagents)IBA 06/2020 - 04/2006
3	Disinfectants (Biocides)IBA 06/2020 - 01/2020
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2016 - 08/2008
3	SolutionsIBA 12/2012 - 02/2002
3	CytokinesIBA 09/2012 - 03/2009
3	fucoidanIBA 01/2012 - 01/2010
3	Hemoglobins (Hemoglobin)IBA 01/2011 - 03/2008
3	Heparin (Liquaemin)FDA LinkGeneric 10/2008 - 10/2006
3	Vasodilator Agents (Vasodilators)IBA 11/2006 - 10/2005
3	Acetylcholine (Acetylcholine Chloride)FDA Link 11/2006 - 10/2005
3	Paclitaxel (Taxol)FDA LinkGeneric 10/2006 - 12/2005
2	SteroidsIBA 01/2023 - 03/2022
2	lime (calcium oxide)FDA Link 06/2020 - 01/2020
2	Biocompatible Materials (Biomaterials)IBA 09/2015 - 06/2015
2	Messenger RNA (mRNA)IBA 01/2015 - 08/2013
2	Biomarkers (Surrogate Marker)IBA 01/2013 - 10/2012
2	CatecholaminesIBA 08/2012 - 10/2004
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 08/2012 - 10/2004
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2011 - 03/2009
2	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 09/2011 - 10/2008
2	atelocollagenIBA 01/2011 - 07/2007
2	salicylhydroxamic acid (SHAM)IBA 09/2010 - 05/2010
2	Radioisotopes (Radionuclides)IBA 01/2009 - 08/2007
2	Polystyrenes (Polystyrene)IBA 10/2008 - 04/2006
1	Blood Glucose (Blood Sugar)IBA 01/2024
1	AlbuminsIBA 04/2023
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2023
1	Bevacizumab (Avastin)FDA Link 01/2023
1	atezolizumabIBA 01/2023

Therapy/Procedure

6	Pedicle Screws 11/2023 - 03/2022
6	Therapeutics 01/2023 - 09/2004
5	Injections 04/2018 - 01/2007
4	Operative Time 11/2023 - 03/2022
4	Minimally Invasive Surgical Procedures 11/2023 - 03/2022
2	Activities of Daily Living (ADL) 03/2024 - 02/2023
2	Decompression 01/2023 - 05/2022
2	Resuscitation 11/2021 - 01/2011
2	Ligation 01/2016 - 09/2010
2	Intramuscular Injections 12/2012 - 11/2012
2	Hemodilution 08/2012 - 08/2008
2	Catheters 01/2011 - 01/2004
2	Transplantation 03/2008 - 07/2007
1	Spinal Fusion (Spondylosyndesis) 11/2023
1	Conservative Treatment 10/2022
1	Bone Transplantation (Bone Grafting) 03/2022